Athletics at Tampa Bay 12:10 PM ET
Shea Langeliers has come off the injured list bashing for the Athletics.
St. Louis at Pittsburgh 12:35 PM ET
Coming off his best start in a decade, St. Louis Cardinals ace Sonny Gray will try to deliver another quality effort when he faces the host Pittsburgh Pirates on Wednesday afternoon.
San Diego at Philadelphia 1:05 PM ET
After a rainout on Tuesday in Philadelphia, the Phillies and the San Diego Padres took different approaches regarding their scheduled starting pitchers for the game that didn't happen.
Minnesota at Miami 6:40 PM ET
Winners of eight games in a row, the Miami Marlins will aim to clinch their fourth consecutive series win on Wednesday night when they host the Minnesota Twins.
Detroit at Washington 6:45 PM ET
The visiting Detroit Tigers will open their three-game series against the Washington Nationals a day later than expected when the teams clash in a day-night doubleheader on Wednesday.
NY Yankees at Toronto 7:07 PM ET
Entering play on the second day of June, the Toronto Blue Jays stood 5 1/2 games behind the New York Yankees in the American League East.
Cincinnati at Boston 7:10 PM ET
The Boston Red Sox and visiting Cincinnati Reds will complete their three-game interleague series with a full Wednesday of action, picking up their suspended game from Tuesday night before playing their regularly scheduled evening contest.
Milwaukee at NY Mets 7:10 PM ET
The Milwaukee Brewers and host New York Mets will play a day-night doubleheader on Wednesday after rain forced the postponement of the series opener on Tuesday.
LA Angels at Atlanta 7:15 PM ET
Atlanta left fielder Jurickson Profar will return to the lineup Wednesday night when the Braves host the Los Angeles Angels in the second contest of their three-game set.
Cleveland at Chi. Cubs 8:05 PM ET
Shota Imanaga returned from injury last week and immediately regained his star form on the mound for the Chicago Cubs.
Baltimore at Texas 8:05 PM ET
Two pitchers who have been underwhelming recently will take the mound when the Baltimore Orioles and Texas Rangers square off Wednesday night in the rubber game of a three-game series in Arlington, Texas.
Houston at Colorado 8:40 PM ET
The Houston Astros are getting unhappy injury updates on a daily basis, but it hasn't stopped them from winning.
Kansas City at Seattle 9:40 PM ET
While Cal Raleigh seemingly has put a stranglehold on the mantle of best catcher in baseball this season, Salvador Perez showed he's not done yet.
San Francisco at Arizona 9:40 PM ET
The Arizona Diamondbacks seem to have found some confidence with the San Francisco Giants in the visiting dugout.
Chi. White Sox at LA Dodgers 10:10 PM ET
The countdown to 3,000 will be at the forefront when Los Angeles Dodgers left-hander Clayton Kershaw takes the mound Wednesday night against the visiting Chicago White Sox.